Se presenta un caso de amebiasis intestinal en el Hospital San Rafael de Alajuela, en un paciente masculino de 42 años, con un cuadro de diarrea mucosanguinolenta de tres semanas de evolución. Además refiere dolor abdominal difuso, pérdida progresiva de peso y apetito asociado a astenia, adinamia y tenesmo. Se le realiza una colonoscopía con biopsia, la cual reveló una enfermedad inflamatoria intestinal severa, debida a la presencia de trofozoitos de Entamoeba histolytica. This is a case of intestinal amebiasis presented at the San Rafael de Alajuela Hospital, in a male patient of 42 years old, suffering from a bloody diarrhea, with an evolution of three weeks. Also be has a diffuse abdominal pain, progressive loss of weight and appetite associated with asthenia, adynamia and difficulty passing stool. A colonoscopy with a biopsy was performed and revealed an intestinal inflammatory disease due to of the presence of trophozoites of Entamoeba histolytica.